Abstract
Comparison of several amine-substituted and methoxy-substituted analogs of N1-(4-aminobenzene)sulfonylindole suggests that these substituents might contribute to the 5-HT6 serotonin receptor affinity of these agents via their electronic effect on the indolic nucleus. Their 1,2,3,4-tetrahydrocarbazole counterparts behave differently.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anisoles / chemistry*
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Anisoles / metabolism
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Binding Sites
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Carbazoles / chemistry*
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Carbazoles / metabolism
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Humans
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Indoles / chemistry
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Indoles / metabolism
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Receptors, Serotonin / metabolism*
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Sulfanilamides / chemistry*
Substances
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Anisoles
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Carbazoles
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Indoles
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Receptors, Serotonin
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Sulfanilamides
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serotonin 6 receptor
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1,2,3,4-tetrahydrocarbazole
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anisole