Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3793-6. doi: 10.1016/j.bmcl.2006.04.094. Epub 2006 May 18.

Abstract

Comparison of several amine-substituted and methoxy-substituted analogs of N1-(4-aminobenzene)sulfonylindole suggests that these substituents might contribute to the 5-HT6 serotonin receptor affinity of these agents via their electronic effect on the indolic nucleus. Their 1,2,3,4-tetrahydrocarbazole counterparts behave differently.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anisoles / chemistry*
  • Anisoles / metabolism
  • Binding Sites
  • Carbazoles / chemistry*
  • Carbazoles / metabolism
  • Humans
  • Indoles / chemistry
  • Indoles / metabolism
  • Receptors, Serotonin / metabolism*
  • Sulfanilamides / chemistry*

Substances

  • Anisoles
  • Carbazoles
  • Indoles
  • Receptors, Serotonin
  • Sulfanilamides
  • serotonin 6 receptor
  • 1,2,3,4-tetrahydrocarbazole
  • anisole